期刊
FEBS LETTERS
卷 594, 期 4, 页码 740-750出版社
WILEY
DOI: 10.1002/1873-3468.13657
关键词
Ap-phr; CRY-DASH; crystal structure; enzyme activity; MTHF
资金
- Chinese National Natural Science Foundation [U1732114, 31971124, 31770788, U1932120, 31770895]
- National Key Research and Development Program of China [2017YFA0503600]
Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to skin cancer. Here, we identified a photolyase from the alga Arthrospira platensis (designated as Ap-phr), which has been regarded as a safe organism for humans for centuries, that can efficiently repair CPD lesions in ssDNA and dsDNA in vitro. The 1.6 angstrom resolution crystal structure of Ap-phr revealed that it possesses a unique methenyltetrahydrofolate chromophore-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications.
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