期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 22, 期 9, 页码 1552-1564出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2016.04.022
关键词
Graft-versus-host disease; Hematopoietic stem cell transplantation; Biomarker; Proteomics
资金
- NCI NIH HHS [P30 CA091842] Funding Source: Medline
- NHLBI NIH HHS [L30 HL124526] Funding Source: Medline
Allogeneic hematopoietic cell transplantation (HCT) is an increasingly used curative modality for hematologic malignancies and other benign conditions. Attempts to reduce morbidity and mortality and improve survival in patients undergoing HCT are crucial. The ability to diagnose acute graft-versus-host disease (aGVHD) in a timely manner, or to even predict aGVHD before clinical manifestations, along with the accurate stratification of these patients, are critical steps to improve the treatment and outcomes of these patients. Many novel biomarkers that may help achieve these goals have been studied recently. This overview is intended to assist clinicians and investigators by providing a comprehensive review and analytical interpretation of the current knowledge concerning aGVHD and biomarkers likely to prove useful in diagnosis and risk stratification of this condition, along with the difficulties that hamper this approach. (C) 2016 American Society for Blood and Marrow Transplantation.
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