期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 22, 期 7, 页码 1159-1166出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2016.03.016
关键词
Hematopoietic cell transplantation; Metabolic syndrome; Survivor; Late effects
资金
- Institutional Research Grant from the American Cancer Society [124166-IRG-58-001-55-IRG22]
- Hyundai Hope on Wheels Young Investigator Clinical Grant
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000114, 5R01A1100879-03]
Hematopoietic cell transplantation (HCT) survivors face a multitude of short- and long-term health complications in the years after treatment. One important health complication that is associated with significant morbidity is metabolic syndrome (MetSyn). This constellation of findings, which includes obesity, glucose and lipid dysmetabolism, and hypertension, places affected individuals at increased risk for type 2 diabetes mellitus, cardiovascular complications, and stroke. Previous studies have linked MetSyn in Ha survivors to prior treatment; however, few studies have addressed the potential roles of systemic inflammation and immune system dysfunction after HOT. Within this review, we address the recent advances in the understanding of adipose tissue biology, immune, and inflammatory mechanisms involved in MetSyn in non-HCT patients, and lastly, we discuss potential novel mechanisms that may play a role in MetSyn development after Ha, such as hematopoietic stem cell source, inflammatory status of the stem cell donor, and microbiome composition, all of which represent potential new directions for post-HCT MetSyn research. (C) 2016 American Society for Blood and Marrow Transplantation.
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