期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 72, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.etap.2019.103263
关键词
NK cells; Lymphocytes; Monocytes; Pentachlorophenol; Dichlorodiphenyltrichloroethane; Interleukin 6
资金
- National Institutes of Health [5T34GM007663, U54CA163066]
The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 mu M (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulated stimulates inflammatory diseases and tumor progression. Immune cells exposed to PCP at 0.05-5 mu M and DDT at 0.025-2.5 mu M showed increased secretion of IL-6 when the cell preparations contained either T lymphocytes or monocytes. Increased IL-6 secretion was due to PCP and DDT induced cellular production of the cytokine and was dependent on MAP kinase signaling pathways (in the case of PCP). Compound-induced increases in IL-6 production were in part due to increases in either the transcription of and/or stability of its mRNA. Thus, both PCP and DDT have the potential to produce chronic inflammation by stimulating production of IL-6 by immune cells.
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