期刊
ENVIRONMENT INTERNATIONAL
卷 132, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2019.105064
关键词
Traffic-related air pollution; Inflammation; Diabetes
资金
- National Institutes of Health, National Institute of Environmental Health Sciences [R01 ES019168]
- Centers for Disease Control and Prevention [00097, DP-05-069, DP-10-001]
- National Institute of Diabetes and Digestive and Kidney Diseases
- University of Colorado Denver [U18DP006139, U48/CCU819241-3, U01 DP000247, U18DP000247-06A1]
- Children's Hospital Medical Center (Cincinnati) [U18DP006134, U48/CCU519239, U01 DP000248, 1U18DP002709]
- University of North Carolina at Chapel Hill [U18DP006138, U48/CCU419249, U01 DP000254, U18DP002708]
- Seattle Children's Hospital [U18DP006136, U58/CCU019235-4, U01 DP000244, U18DP002710-01, UL1 TR00423]
- Wake Forest University School of Medicine [U18DP006131, U48/CCU919219, U01 DP000250, 200-2010-35171]
- South Carolina Clinical & Translational Research Institute, at the Medical University of South Carolina, NIH/National Center for Advancing Translational Sciences (NCATS) [UL1 TR000062]
- University of Washington, NIH/NCATS grant [UL1 TR00423]
- University of Colorado Pediatric Clinical and Translational Research Center, NIH/NCATS [UL1 TR000154]
- Barbara Davis Center at the University of Colorado at Denver (DERC NIH grant) [P30 DK57516]
- University of Cincinnati, NIH/NCATS grant [UL1 TR000077]
- Children with Medical Handicaps program
- Kaiser Permanente Southern California [U48/CCU919219, U18DP006133, U01 DP000246, U18DP002714]
Background: Evidence remains equivocal regarding the association of inflammation, a precursor to cardiovascular disease, and acute exposures to ambient air pollution from traffic-related particulate matter. Though youth with type 1 diabetes are at higher risk for cardiovascular disease, the relationship of inflammation and ambient air pollution exposures in this population has received little attention. Objectives: Using five geographically diverse US sites from the racially- and ethnically-diverse SEARCH for Diabetes in Youth Cohort, we examined the relationship of acute exposures to PM2.5 mass, Atmospheric Dispersion Modeling System (ADMS)-Roads traffic-related PM concentrations near roadways, and elemental carbon (EC) with biomarkers of inflammation including interleukin-6 (IL-6), c-reactive protein (hs-CRP) and fibrinogen. Methods: Baseline questionnaires and blood were obtained at a study visit. Using a spatio-temporal modeling approach, pollutant exposures for 7 days prior to blood draw were assigned to residential addresses. Linear mixed models for each outcome and exposure were adjusted for demographic and lifestyle factors identified a priori. Results: Among the 2566 participants with complete data, fully-adjusted models showed positive associations of EC average week exposures with IL-6 and hs-CRP, and PM2.5 mass exposures on lag day 3 with IL-6 levels. Comparing the 25th and 75th percentiles of average week EC exposures resulted in 8.3% higher IL-6 (95%CI: 2.7%,14.3%) and 9.8% higher hs-CRP (95%CI: 2.4%,17.7%). We observed some evidence of effect modification for the relationships of PM2.5 mass exposures with hs-CRP by gender and with IL-6 by race/ethnicity. Conclusions: Indicators of inflammation were associated with estimated traffic-related air pollutant exposures in this study population of youth with type 1 diabetes. Thus youth with type 1 diabetes may be at increased risk of air pollution-related inflammation. These findings and the racial/ethnic and gender differences observed deserve further exploration.
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