期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 22, 期 11, 页码 2100-2103出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2016.08.002
关键词
Donor-derived leukemia; TET2 mutation; Clonal hematopoiesis of indeterminate potential
资金
- American Society of Hematology through the ASH HONORS Award [061273]
- Cancer Research Foundation [060015]
- NCI [K12 CA139160]
- NHLBI [K08 HL129088]
Analysis of the clinical characteristics of hematopoietic stem cell transplant (HSCT) donors has proven beneficial for identifying cases of heritable hematopoietic disorders. This study examines poor peripheral blood hematopoietic stem cell mobilization after granulocyte colony-stimulating factor administration among 328 donors as a potential marker for suspected familial predisposition to myeloid malignancies. Here, we present data comparing the clinical characteristics of poor-mobilizing versus nonpoor-mobilizing donors and the results of panel-based sequencing of hematopoietic genes in poor-mobilizing donors. From this analysis, we identified a novel case of a donor-derived myelodysplastic syndrome in an HSCT recipient that is consistent with clonal evolution of TET2-mutated clonal hematopoiesis of indeterminate potential (CHIP) within the donor. This study demonstrates the potential risk of using hematopoietic stem cells from a donor with CHIP and raises the question of whether there should be increased screening measures to identify such donors. (C) 2016 American Society for Blood and Marrow Transplantation.
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