期刊
EMBO MOLECULAR MEDICINE
卷 11, 期 12, 页码 -出版社
WILEY
DOI: 10.15252/emmm.201810234
关键词
age-related disorders; cellular senescence; SASP; senolytic drugs; senoprobes
资金
- Cancer Research UK (CRUK) Cambridge Centre Early Detection Programme
- CRUK Early Detection OHSU Project Award
- Medical Research Council (MRC) New Investigator Research Grant (NIRG)
- Royal Society Research Grant
- La Caixa Foundation Scholarship for postgraduate studies at European Universities
- MRC [MR/R000530/1] Funding Source: UKRI
Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs during ageing, contribute to tissue dysfunction and give rise to pathological manifestations. Senescence is therefore a defining feature of a variety of human age-related disorders, including cancer, and targeted elimination of these cells has recently emerged as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration. In addition, in vivo identification of senescent cells has significant potential for early diagnosis of multiple pathologies. Here, we review existing senolytics, small molecules and drug delivery tools used in preclinical therapeutic strategies involving cellular senescence, as well as probes to trace senescent cells. We also review the clinical research landscape in senescence and discuss how identifying and targeting cellular senescence might positively affect pathological and ageing processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据