期刊
ELECTROANALYSIS
卷 32, 期 2, 页码 301-307出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201900145
关键词
Captopril; Rutin; Graphite Paste Electrode; Cyclic voltammetry; Antihypertensive drug
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
A simple, rapid and sensitive cyclic voltammetry method is described for the determination of the antihypertensive drug captopril in aqueous solution using a graphite paste electrode with rutin as mediator. The catalytic role of rutin in the oxidation of captopril was confirmed by the increase observed in anodic peak current at+0.44 V vs. SCE in the presence of the mediator. Anodic peak current varied linearly with the concentration of captopril in the dynamic range 0.2 to 1.0 mmol L-1. The method exhibited a limit of detection of 89.4 mu mol L-1 and a reproducibility of 1 %, values that are comparable with those exhibited by other methodologies employing electrodes without any modification. The recovery rate for the determination of captopril in a pharmaceutical sample was good (91.21 %) suggesting that the described analytical technique would be effective in industrial applications whilst offering a number of advantages over published cyclic voltammetric methods.
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