期刊
DYES AND PIGMENTS
卷 174, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2019.108059
关键词
Ratiometric fluorescent probe; 3-hydroxyflavone; Group IIIA ions; Bioimaging
资金
- National Natural Science Foundation of China [31800833, 21977081]
- Zhejiang Provincial Natural Science Foundation of China [Z19H180001, LY17C010004]
- Wenzhou Medical University
- Wenzhou Institute of Biomaterials Engineering [WISEZD2017001-03]
- National Health Commission [wkj-zj-1707]
Gallium, aluminum, and indium belong to Group IIIA of the periodic table with similar chemical properties, which were a double-edged sword for living organisms. Therefore, it's particularly important to detect the content of Group IIIA in organisms. Obviously, the fluorescent probe method has become a mainstream method for detecting metal ions with advantages of convenience and high efficiency. Unfortunately, fluorescent probes that can simultaneously detect these three metal ions are rarely reported. 3-hydroxyflavone (3-HF) is a highly focused molecule with chemical and photochemical properties and have great potential for bioimaging applications as sensors with excited-state intramolecular proton transfer (ESIPT). Here, 3-HF as ratiometric fluorescence probes have been developed for responding to Group IIIA ions including Ga(III), Al(III) and In(III) ions with ESIPT-based mechanism. 3-HF displayed highly specific sensing for Group IIIA ions over other cations with a green fluorescence transformation into blue fluorescence by the formation of 2:1 complexes. However, rapid response toward Group IIIA ions was developed using ratiometric fluorescence with wide pH range and good reversibility, and the response mechanism of 3-HF toward Group IIIA ions was annotated by density functional theory (DFT). Furthermore, the biological applicability of 3-HF has shown that 3-HF were able to detect and image Group MA ions in cells. Additionally, using a zebrafish model, we exhibited the capability of this 3-HF probe for detecting and imaging Group IIIA ions in zebrafish. This work achieves the detection and imaging of Group IIIA simultaneously by 3-HF probe in living cells and zebrafish and provides another example for ESIPT OFF.
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