期刊
DRUG AND CHEMICAL TOXICOLOGY
卷 45, 期 1, 页码 223-230出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01480545.2019.1680687
关键词
Tamarix; tamarisk; halophyte; phytochemical; polyphenol; flavonoid
资金
- Tehran University of Medical Sciences [96-04-86-37025]
This study assessed the phytochemical and toxicological properties of T. stricta, a plant native to Iran. The results showed that the extract of T. stricta is rich in polyphenols and showed no signs of toxicity. Further pharmacological evaluations are recommended to explore the therapeutic properties of this plant.
The genus Tamarix includes several plant species well-known for their medicinal properties since ancient times. Tamarix stricta Boiss is a plant native to Iran which has not been previously investigated regarding its phytochemical and biological properties. This study assessed phytochemical and toxicological aspects of T. stricta. The plant was collected from Kerman province of Iran and after authentication by botanist, it was extracted with 70% ethanol. Total phenolic compounds, total flavonoids, and antioxidant properties were measured using spectrophometric methods. Quercetin content of the extract was measured after complete acid hydrolysis with high-performance liquid chromatography. The phytochemical profile of the extract was provided using liquid chromatography-mass spectrometry method. Acute toxicity study with a single intragastric dose of 5000 mg/kg of the extract and sub-chronic toxicity using 50, 100, and 250 mg/kg of the extract was assessed in Wistar rats. Phytochemical analysis showed that polyphenols constitute the major components of the extract. Also, the extract contained 1.552 +/- 0.35 mg/g of quercetin. Biochemical, hematological, and histological evaluations showed no sign of toxicity in animals. Our experiment showed that T. stricta is a rich source of polyphenols and can be a safe medicinal plant. Further pharmacological evaluations are recommended to assess the therapeutic properties of this plant.
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