期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 96, 期 3, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2019.114955
关键词
Rapid identification; Phenotypic antimicrobial susceptibility testing; Blood culture; Antimicrobial therapy
资金
- Ministry of University and Scientific Research Grant FIL, Parma, Italy
The Accelerate Phenon (TM) System (APS), a new platform that combines rapid identification (ID) of bacteria and yeasts and phenotypic antimicrobial susceptibility testing (AST) in a single assay, has been evaluated directly from positive blood cultures in comparison to routine laboratory methods. The APS ID results showed an overall sensitivity and specificity of 92.6% and 99.6%, respectively. With regard to AST results, 31 discrepancies (8 single errors and 23 combined errors) were observed, including 13 major errors (3.3%) and 18 minor errors (4.6%) mainly involving Pseudomonas aeruginosa. No very major error was observed. The APS ID results were obtained in 1.5 h and the AST results were available in 7 h, on average 34.1 h before routine laboratory methods. This reduction in AST time-to-result represents one of the main advantages of this technology, reducing the time to provide to the physician the microbiological report. (C) 2019 Elsevier Inc. All rights reserved.
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