期刊
DENTAL MATERIALS JOURNAL
卷 38, 期 6, 页码 1036-1042出版社
JAPANESE SOC DENTAL MATERIALS DEVICES
DOI: 10.4012/dmj.2018-112
关键词
Chitosan; Fluoride varnish; Sustained release
资金
- 90th Year Chulalongkorn Scholarship from the Ratchadapisek Somphot Fund, Chulalongkorn University
Fluoride varnish is a professionally applied product that prevents dental caries. However, fluoride varnishes do not provide sustained fluoride release. The objective of this study was to prepare fluoride varnish formulations containing various amounts of chitosan that would generate sustained fluoride release. We evaluated their chemical structure, viscosity, and in vitro fluoride release. Furthermore, the 3-(4, 5-dimethylthiazolyl-2)-2,5diphenyltetrazolium bromide (MTT) assay and direct contact test were used to determine varnish cytotoxicity. We found that all fluoride varnish formulations had the same chemical structure. Their viscosity demonstrated a chitosan concentration-dependent increase. In vitro fluoride release showed a sustained fluoride release. The chitosan fluoride varnishes were cytotoxic to human gingival fibroblasts. We propose the new fluoride varnish formulation as a potential material to be used as a sustained release fluoride varnish.
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