期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 52, 期 -, 页码 68-75出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2019.11.002
关键词
Senescence; Polyploid giant cells; Chemoresistance; Senescence-associated secretory phenotype; Tumor microenvironment
资金
- MHRD Govt. of India
- Indian Institute of Technology Kharagpur, India
- J C Bose National Fellowship, India
- Indian Council of Medical Research
Cellular senescence has been associated with age-related diseases, wound healing, fibrosis, diabetes and cancer. Senescent cells lack the capacity to proliferate, but are known to aggravate tumorigenesis. The polyploid giant cells arise from the cancer cell population mainly due to genotoxic stress caused by chemotherapy and/or radiotherapy. They exhibit features of senescence and have been reported to secrete an array of cytokines, chemokines and growth factors. These small molecules can bind to their receptors located on the surface of neighboring cells and activate/deactivate relevant signaling pathways, thereby modulating the tumor microenvironment. Some of these signaling cascade(s) might play a role in imparting therapy resistance to the cancer cells. This review throws light on the incidence of senescence and how the senescent polyploid giant cells affect the tumor microenvironment. Their role in giving rise to chemoresistant cancer cell population as well as acquired chemoresistance in the neighboring cancer cells along with various potential and established therapeutic avenues have also been discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据