期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 49, 期 -, 页码 23-31出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2019.10.004
关键词
Receptor tyrosine kinase; Signaling; Growth factor; Interactions
资金
- National Science foundation (NSF) [MCB 1712740]
- National Institutes of health (NIH) [GM068619]
Here, we discuss the transition model of receptor tyrosine kinase (RTK) activation, which is derived from biophysical investigations of RTK interactions and signaling. The model postulates that (1) RTKs can interact laterally to form dimers even in the absence of ligand, (2) different unliganded RTK dimers have different stabilities, (3) ligand binding stabilizes the RTK dimers, and (4) ligand binding causes structural changes in the RTK dimer. The model is grounded in the principles of physical chemistry and provides a framework to understand RTK activity and to make predictions in quantitative terms. It can guide basic research aimed at uncovering the mechanism of RTK activation and, in the long run, can empower the search for modulators of RTK function.
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