期刊
CURRENT PHARMACEUTICAL DESIGN
卷 25, 期 34, 页码 3599-3607出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612825666191014163923
关键词
Spheroid; 3D cell culture; drug resistance; drug discovery; cancer therapy; 2D monolayer
The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture is a more accurate cell culture model to test the effectiveness of anticancer drugs or characterization of cancer cells in comparison with two dimensional (2D) monolayer. This study underpins various factors that cause resistance to anti-cancer drugs in forms of spheroids in 3D in-vitro cell culture and also outlines key challenges and possible solutions for the future development of these systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据