期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 173, 期 2, 页码 501-513出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-016-0676-5
关键词
Selenium deficiency; Chicken; Aorta vessel; Selenoprotein; Inflammatory cytokine
资金
- International (Regional) Cooperation and Exchange Projects of the National Natural Science Foundation of China [31320103920]
- National Natural Science Foundation of China [31272626]
Selenium deficiency is known to cause cardiovascular diseases. However, the role of Se deficiency in causing oxidative damage and inflammation injury to the aorta vessels of chickens is not well known. In the present study, 180 1-day-old chickens were randomly divided into two groups, a low-Se group (L group) and a control-Se group (C group). The messenger RNA (mRNA) levels of 25 selenoproteins, the mRNA and protein expression levels of inflammatory cytokines (including NF-kappa B, TNF-alpha, COX-2, and PTGES), and the antioxidant levels in chicken aorta vessels were examined. The results showed that the mRNA levels of 25 selenoproteins and the activity of Gpx were decreased, while the mRNA and protein expression levels of inflammatory cytokines and the MDA content were increased by Se deficiency in chicken aorta vessels. The data from the present study indicated that Se deficiency decreases the expression of selenoproteins, reduces antioxidant function, and increases the expression of inflammatory factors in chicken aorta vessels.
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