期刊
CURRENT OPINION IN MICROBIOLOGY
卷 51, 期 -, 页码 9-15出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2019.03.003
关键词
-
类别
资金
- Cystic Fibrosis Canada
- Boris Family Foundation
- Canadian Institutes of Health Research
Bacteria and fungi are prolific producers of secondary metabolites, yet they house a multitude of silent biosynthetic gene clusters that are poorly expressed and whose products are unknown or 'cryptic'. Stimulating the expression of these clusters and accessing their associated molecules is a major priority, as they are expected to have a veritable cornucopia of bioactivites. Here, we highlight three strategies that have been the focus of recent developments. Co-culture and elicitor screening, genetic regulator investigation and exploitation, and pathway refactoring and heterologous cluster expression, are collectively being employed to activate the expression of cryptic biosynthetic gene clusters (BGCs), and stimulate the production of novel metabolites having diverse activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据