期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 52, 期 -, 页码 112-124出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.06.006
关键词
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资金
- NCCR Chemical Biology
- Swiss National Science Foundation
- ERC
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.
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