期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 59, 期 -, 页码 55-64出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.02.006
关键词
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资金
- US National Science Foundation [CBET-1264052, CBET-1264053, CBET-1802939]
- US Air Force Office of Scientific Research (AFOSR) [FA9550-13-1-0236, FA9550-17-1-0268]
- U.S. Department of Agriculture [NIFA 2018-67021-27716, DE-FG05-95ER20175]
- U.S. Department of Education GAANN Fellowship [P200A140020, P200A160061]
Going forward, industrial biotechnology must consider non-model metabolic engineering platforms if it is to have maximal impact. This will include microorganisms that natively possess strategic physiological and metabolic features but lack either molecular genetic tools or such tools are rudimentary, requiring further development. If non-model platforms are successfully deployed, new avenues for production of fuels and chemicals from renewable feedstocks or waste materials will emerge. Here, the challenges and opportunities for extreme thermophiles as metabolic engineering platforms are discussed.
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