期刊
CURRENT MEDICINAL CHEMISTRY
卷 26, 期 24, 页码 4681-4696出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190614123835
关键词
Solid lipid nanoparticles; nanostructurcd lipid carriers; active natural compounds; drug delivery; stability; carrier systems
Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.
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