The fate of dietary advanced glycation end products in the body: from oral intake to excretion

Advanced glycation end products (AGEs), which are closely associated with various chronic diseases, are formed through the Maillard reaction when aldehydes react with amines in heated foods or in living organisms. The fate of dietary AGEs after oral intake plays a crucial role in regulating the association between dietary AGEs and their biological effects. However, the complexity and diversity of dietary AGEs make their fate ambiguous. Glycated modifications can impair the digestion, transport and uptake of dietary AGEs. High and low molecular weight AGEs may exhibit individual differences in their distribution, metabolism and excretion. Approximately 50-60% of free AGEs are excreted after dietary intake, whereas protein-bound AGEs exhibit a limited excretion rate. In this article, we summarize several AGE classification criteria and their abundance in foods, and in the body. A standardized static in vitro digestion method is strongly recommended to obtain comparable results of AGE digestibility. Sophisticated hypotheses regarding the intestinal transportation and absorption of drugs, as well as calculated physicochemical parameters, are expected to alleviate the difficulties determining the digestion, transport and uptake of dietary AGEs. Orally supplied AGEs with low or high molecular weights must be supported by well-defined amounts in investigations of excretion. Furthermore, unequivocal evidence should be obtained regarding the degradation and metabolism products of dietary AGEs.