期刊
BIOLOGICAL RESEARCH FOR NURSING
卷 18, 期 1, 页码 50-59出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1099800414568661
关键词
grief; blame; caregivers; cytokines; brain injury; TNF-alpha; anger
类别
资金
- Department of Veterans Affairs Nursing Research Initiative [HSRD NRI 12-413]
Grief, although traditionally conceptualized as a bereavement-related reaction, is also experienced by significant others in response to the profound cognitive and personality changes associated with a traumatic brain injury (TBI) in a loved one. Grief associated with the death of a loved one is related to increases in proinflammatory cytokines, yet it is not clear whether this is the case for grief experienced by individuals caring for a significant other with TBI. The purpose of this cross-sectional, exploratory study was to examine grief and its association with a proinflammatory cytokine, tumor necrosis factor (TNF-), in wives/partners caring for veterans with TBI. Participants completed written measures of grief, perceived stress, and depressive symptoms and provided morning saliva samples for TNF- analysis. Participants reported levels of grief comparable to those reported in studies evaluating individuals grieving the death of a loved one. Path analysis revealed that grief was not associated with TNF-; however, participants reporting high levels of blame/anger, a subscale of the grief scale, had higher levels of TNF-. In addition, both grief and blame/anger were related to increased perceived stress and depressive symptoms; however, path analysis demonstrated that perceived stress and depressive symptoms did not mediate the influence of blame/anger on TNF-. These findings suggest that blame/anger associated with grief may be related to the elevations in TNF- exhibited by individuals caring for a loved one with TBI.
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