期刊
BIOLOGICAL PSYCHOLOGY
卷 118, 期 -, 页码 79-87出版社
ELSEVIER
DOI: 10.1016/j.biopsycho.2016.05.002
关键词
Prediction of alcohol consumption; Adolescents
资金
- European Union [LSHM-CT- 2007-037286]
- FP7 project IMAGEMEND
- Innovative Medicine Initiative Project EU-AIMS [115300-2]
- Medical Research Council Programme Grant [93558]
- Swedish funding agency FORMAS
- Bundesministerium fur Bildung und Forschung (NGFN Plus) [FKZ: 01GS08152, 01EV0711]
- Bundesministerium fur Bildung und Forschung (project AERIAL grant) [01EE1406C]
- Deutsche Forschungsgemeinschaft (Reinhart-Koselleck Award) [SP 383/5-1, HE 7288/2-1]
- ANR [AF12-NEUR0008-01 - WM2NA]
- Mission Interministerielle de Lutte contre la Drogue et la Toxicomanie (MILDT)
- Fondation de France
- Fondation pour la Recherche Medicale
- Olympia-Morata-Program of the University of Heidelberg
- Janssen McNeil
- Lilly
- Medice
- Novartis
- Shire
- German Federal Ministry of Education and Research
- AstraZeneca
- Eli Lilly Co
- Janssen-Cilag
- Bristol-Myers Squibb
- German Research Foundation
- Bernstein Centerfor Computational Neuroscience Berlin (German Federal Ministry of Education and Research)
- Eli Lilly Co.
- European Commission
- Stifterverband fur die Deutsche Wissenschaft
- Berlin Brandenburgische Akademie der Wissenschaften
- Boehringer Ingelheim Fonds
- Eli Lilly International Foundation
- Pfizer
- Lundbeck A/S, Copenhagen
- MRC [G0901858] Funding Source: UKRI
- Medical Research Council [G0901858] Funding Source: researchfish
Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced.
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