期刊
BIOLOGICAL PSYCHIATRY
卷 79, 期 3, 页码 251-257出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2015.06.016
关键词
Bias; Effect size; Neuroendocrinology; Positive predictive value; Social cognition; Statistical power
资金
- National Institutes of Health [R01MH096983, 1P50MH100023]
- National Institutes of Health Office of the Director [P51OD11132]
- Swedish Brain Foundation
Over the last decade, oxytocin (OT) has received focus in numerous studies associating intranasal administration of this peptide with various aspects of human social behavior. These studies in humans are inspired by animal research, especially in rodents, showing that central manipulations of the OT system affect behavioral phenotypes related to social cognition, including parental behavior, social bonding, and individual recognition. Taken together, these studies in humans appear to provide compelling, but sometimes bewildering, evidence for the role of OT in influencing a vast array of complex social cognitive processes in humans. In this article, we investigate to what extent the human intranasal OT literature lends support to the hypothesis that intranasal OT consistently influences a wide spectrum of social behavior in humans. We do this by considering statistical features of studies within this field, including factors like statistical power, prestudy odds, and bias. Our conclusion is that intranasal OT studies are generally underpowered and that there is a high probability that most of the published intranasal OT findings do not represent true effects. Thus, the remarkable reports that intranasal OT influences a large number of human social behaviors should be viewed with healthy skepticism, and we make recommendations to improve the reliability of human OT studies in the future.
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