期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 183, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.110454
关键词
Periodontitis; Microenvironment; Polyphosphoester; Enzyme-responsive drug release; Periodontal tissue repair
资金
- National Natural Science Foundation of China [51373099]
- Lanzhou Talent innovation and entrepreneurship project [2015-RC-19]
- Lanzhou Key projects of Health Science and technology development [LZWSKY2014-1-01]
- Shanghai Education Commission for scientific research plan of university teachers and Guangci Distinguished Young Scholars Training Program [GCQN-2017-B13]
Periodontitis is a chronic, destructive inflammatory disease that injures tooth- supporting tissues, eventually leading to tooth loss. Complete eradication of periodontal pathogenic microorganisms is fundamental to allow periodontal healing and commonly precedes periodontal tissue regeneration. To address this challenge, we report a strategy for developing an enzyme-mediated periodontal membrane for targeted antibiotic delivery into infectious periodontal pockets; the unique components of the membrane will also benefit periodontal alveolar bone repair. In this approach, a chitosan membrane containing polyphosphoester and minocycline hydrochloride (PPEM) was prepared. Physical, morphological, and ultrastructural analyses were carried out in order to assess cellular compatibility, drug release and antibacterial activity in vitro. Additionally, the functionality of the PPEM membrane was evaluated in vivo with a periodontal defect model in rats. The results confirm that the PPEM membrane exhibits good physical properties with excellent antibacterial activity and successfully promotes periodontal tissue repair, making it promising for periodontal treatment.
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