期刊
BIOLOGICAL PSYCHIATRY
卷 79, 期 4, 页码 266-273出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2015.03.025
关键词
Default mode network; fMRI; Functional connectivity; Major depressive disorder; Transcutaneous vagus nerve stimulation; Vagus nerve stimulation
资金
- Chinese National Natural Science Foundation [30870668, 81273674]
- Chinese National Natural Science Foundation Research [30973798, 81473780]
- National Basic Research Program of China (973 Program) [2012CB518503]
- National Twelfth Five-Year Plan of the National Science and Technology Support Program of China [2012BAF14B10]
- Natural Science Foundation of Beijing China [7111007]
- National Institutes of Health/National Center for Complementary and Integrative Health [R01AT006364, P01 AT006663]
- Ministry of Science and Technology [2011EG152313]
BACKGROUND: Depression is the most common form of mental disorder in community and health care settings and current treatments are far from satisfactory. Vagus nerve stimulation (VNS) is a Food and Drug Administration approved somatic treatment for treatment-resistant depression. However, the involvement of surgery has limited VNS only to patients who have failed to respond to multiple treatment options. Transcutaneous VNS (tVNS) is a relatively new, noninvasive VNS method based on the rationale that there is afferent/efferent vagus nerve distribution on the surface of the ear. The safe and low-cost characteristics of tVNS have the potential to significantly expand the clinical application of VNS. METHODS: In this study, we investigated how tVNS can modulate the default mode network (DMN) functional connectivity (FC) in mild or moderate major depressive disorder (MDD) patients. Forty-nine MDD patients were recruited and received tVNS or sham tVNS (stVNS) treatments. RESULTS: Thirty-four patients completed the study and were included in data analysis. After 1 month of tVNS treatment, the 24-item Hamilton Depression Rating Scale score reduced significantly in the tVNS group as compared with the stVNS group. The FC between the DMN and anterior insula and parahippocampus decreased; the FC between the DMN and precuneus and orbital prefrontal cortex increased compared with stVNS. All these FC increases are also associated with 24-item Hamilton Depression Rating Scale reduction. CONCLUSIONS: tVNS can significantly modulate the DMN FC of MDD patients; our results provide insights to elucidate the brain mechanism of tVNS treatment for MDD patients.
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