期刊
CLINICAL CANCER RESEARCH
卷 26, 期 2, 页码 344-353出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-19-0647
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资金
- Bristol-Myers Squibb
- NIH [R01 CA181683-01A1]
- Leukemia and Lymphoma Society
- Multiple Myeloma Research Foundation (MMRF)
Purpose: Ulocuplumab (BMS-936564) is a first-in-class fully human lgG4 monoclonal anti-CXCR4 antibody that inhibits the binding of CXCR4 to CXCL12. Patients and Methods: This phase Ib/II study aimed to determine the safety and tolerability of ulocuplumab alone and in combination with lenalidomide and dexamethasone (Arm A), or bortezomib and dexamethasone (Arm B), in patients with relapsed/refractory multiple myeloma. Results: Forty-sec patients were evaluated (median age, 60 years; range, 53-67). The median number of prior therapies was 3 (range, 1-11), with 70% of subjects having received >= 3. This trial had a dose-escalation and a dose-expansion part. Using a 3+3 design on both arms of the trial, ulocuplumab's dose was escalated to a maximum of 10 mg/kg without reaching MTD. The most common treatment-related adverse events (AE) were neutropenia (13 patients, 43.3%) in Arm A and thrombocytopenia (6 patients, 37.5%) in Arm B. No deaths related to study drugs occurred. The combination of ulocuplumab with lenalidomide and dexamethasone showed a high response rate (PR or better) of 55,2% and a clinical benefit rate of 72,4%, even in patients who had been previously treated with immunomodulatory agents (1MiD). Conclusions: This study showed that blockade of the CXCR4-CXCL12 axis by ulocuplumab is safe with acceptable AEs and leads to a high response rate in combination with lenalidomide and dexamethasone in patients with relapsed/refractory myelorna, making CXCR4 inhibitors a promising class of antimyeloma drugs that should be further explored in clinical trials,
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