期刊
CLINICA CHIMICA ACTA
卷 501, 期 -, 页码 222-228出版社
ELSEVIER
DOI: 10.1016/j.cca.2019.10.042
关键词
Aneurysm; Aortic dissection; Canonical TGF-beta signaling; Non-canonical TGF-beta signaling
资金
- National Natural Science Foundation of China [81670424, 81900424]
- Key Scientific Research Fund of the Hunan Provincial Education Department [15A166]
- Scientific Research Fund of the Hunan Provincial Health and Family Planning Commission [B2016087, B20180058, B20180874]
- National Natural Science Foundation of Hunan Province [2018JJ2345, 2019JJ40258, 2019JJ50502, 2015JJ2118]
- Scientific Research Fund of the Security Bureau of China [hunan-0013-2016AQ]
- Hunan Science and Technology Department Project [2017JJ3141]
- Changsha Science and Technology Bureau Project [kq1706026]
- Innovation of College Students in Hunan Province [S201910555035]
- Project of Research Study and Innovative Experiment Programme for College Students at the University of South China [2017XJXZ031, 2017XJYZ048, 2018XJXZ375, X2019131]
Aortic dissection and aortic aneurysms are currently among the most high-risk cardiovascular diseases due to their rapid onset and high mortality. Although aneurysm research has been extensive, the pathogenesis remains unknown. Studies have found that the TGF-beta/Smad pathway and aneurysm formation appear linked. For example, the TGF-beta signaling pathway was significantly activated in aneurysm development and aortic dissection. Aneurysms are not, however, mitigated following knockdown of TGF-beta signaling pathway-related genes. Incidence and mortality rate of ruptured thoracic aneurysms increase with the down-regulation of the classical TGF-beta signaling pathway. In this review, we summarize recent findings and evaluate the differential role of classical and non-classical TGF-beta pathways on aortic aneurysm. It is postulated that the TGF-beta signaling pathway is necessary to maintain vascular function, but over-activation will promote aneurysms whereas over-inhibition will lead to bypass pathway over-activation and promote aneurysm occurrence.
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