期刊
CLINICA CHIMICA ACTA
卷 497, 期 -, 页码 178-188出版社
ELSEVIER
DOI: 10.1016/j.cca.2019.07.037
关键词
Neurodegeneration; Biomarker; Lipid peroxidation; Biological sample; Blood
资金
- Health Research Institute Carlos III (Spanish Ministry of Economy and Competitiveness) [CP16/00082]
- Health Research Institute Carlos III (Spanish Ministry of Economy, Industry and Competitiveness) [CP16/00082]
Neurodegenerative diseases have great social and economic impact and cause millions of deaths every year. The potential molecular mechanisms in these pathologies have been widely studied and implicate lipid peroxidation as an important factor in the development of neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. Data indicates that pathologic mechanisms specifically involve ferroptosis and mitochondrial dysfunction. Here we review the molecular mechanisms related to the lipid peroxidation that involve the development of neurodegeneration, as well as the utility of some biomarkers in diagnosis, prognosis and evaluation of new therapies for neurodegenerative diseases.
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