Cyclocarya paliurus (Batal.) Iljinskaja polysaccharides alleviate type 2 diabetes mellitus in rats by resisting inflammatory response and oxidative stress

This study aimed to investigate the effects of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharides (CPP) on the glucose-lipid metabolism in T2DM rats. T2DM model was established in 40 Wistar rats which were then randomly divided into model, CPP-1, CPP-2 and CPP-3 groups. Ten normal rats were selected as the control group. The CPP-1, CPP-2 and CPP-3 group were intragastrically administrated with 100, 200 and 400 mg/kg CPP for 4 weeks, respectively. Results showed that, during the treatment, compared with model group, in CPP treatment groups the T2DM symptoms were lightened, and the body weight was improved. After treatment, compared with model group, in CPP-3 group the blood fasting plasma glucose, fasting insulin and glycosylated hemoglobin levels were reduced (P < 0.05), the blood total cholesterol, triglyceride and low-density lipoprotein cholesterol levels were decreased (P < 0.05), the serum C-reactive protein, tumor necrosis factor a and interleukin 6 levels were decreased (P < 0.05), the serum malondialdehyde level was reduced (P < 0.05), and the serum superoxide dismutase and glutathione peroxidase levels were increased (P < 0.05). In conclusion, CPP can alleviate the T2DM in rats, which may be related to its resisting inflammatory response and oxidative stress in body.