期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 15, 期 1, 页码 79-84出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201901429
关键词
acylation; anhydrides; flow chemistry; beta-amino acids
资金
- Japan Society for the Promotion of Science [2707, 16H01138]
- Naito Foundation Natural Science Scholarship
- [19J14624]
- Grants-in-Aid for Scientific Research [16H01138] Funding Source: KAKEN
beta-Amino acid N-carboxy anhydrides (beta-NCAs) are rarely used in the synthesis of beta-peptides, which is due mainly to the poor availability of these potentially useful substrates. Herein, we describe the heretofore challenging synthesis of beta-NCAs via a single-step, rapid, and mild formation using pH flash switching and flash dilution, which are aspects of micro-flow technology. We synthesized 15 beta-NCAs in good to excellent yields that included acid-labile beta-NCAs that cannot be readily synthesized using the conventional Leuchs approach. Scaled-up synthesis using this process can be readily achieved via continuous operation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据