期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 62, 页码 14223-14229出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201903362
关键词
amination; catalysis; cross-coupling; PEPPSI; rate study; selective
资金
- NSERC Canada
- Eli Lilly Research Award Program (LRAP)
The relative rates of arylation of primary alkylamines with different Pd-NHC catalysts have been measured, as have the relative rates of arylation of the secondary aniline product in an attempt to understand the key ligand design features necessary to have high selectivity for the monoarylated amine product. As the substituents on the N-aryl ring of the NHC increase in size, selectivity for monoarylation increases and this is further enhanced by chlorinating the back of the NHC ring. Computations have been performed on the catalytic cycle of this transformation in order to understand the selectivity obtained with the different catalysts.
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