期刊
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
卷 55, 期 11, 页码 1120-1123出版社
SPRINGER
DOI: 10.1007/s10593-019-02587-2
关键词
dimethylaminoquinolines; hydroxyquinolines; methoxyquinolines; quinolones; hydrogen bonding; nucleophilic substitution; proton sponges; tautomerism
资金
- Southern Federal University [VnGr 07/2017-18]
Demethylation of methoxy groups in 6(8)-methoxy-2,4,5-tris(dimethylamino)quinolines with 48% HBr leads to nucleophilic substitution of the 4-NMe2 group with the formation of quinolones existing in solution and the solid state in the hydroxy form stabilized by intramolecular hydrogen bonding. Unlike HBr, the use of BBr3 in the case of the 8-methoxy derivative leads to the formation of 8-hydroxy-2,4,5-tris(dimethylamino)quinoline, a promising ligand for binding of both protic and Lewis acids.
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