期刊
CHEMISTRY & BIODIVERSITY
卷 16, 期 12, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900519
关键词
deep sea fungus; Botryotinia fuckeliana; pimarane diterpenoid; Snatzke's method; cytotoxicity
资金
- Scientific Research Foundation of Third Institute of Oceanography [2018009]
- National Natural Science Foundation of China [41606185]
- COMRA program [DY135-B2-08]
A new pimarane diterpenoid, named botryopimarene A (1), was discovered from the fungus Botryotinia fuckeliana MCCC 3 A00494 isolated from the deep-sea water, together with ten known compounds. The planar structure of 1 was established based on the extensive spectroscopic analyses. The absolute configurations of tricyclic system in 1 were resolved by the theoretical ECD calculation, while the 15,16-diol moiety in the side chain was resolved by the Mo-2(OAc)(4)-induced ECD spectrum. Compound 1, featuring a Delta(9(11)) double bond, was rarely discovered in pimarane family. Compounds 1-11 were tested for their cytotoxic activities using six human cancer cell lines by the MTT method. However, none of the compounds exhibited detectable cytotoxicities (IC50 >20 mu m).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据