期刊
CHEMICAL RECORD
卷 20, 期 6, 页码 541-555出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201900058
关键词
Morita-Baylis-Hillman adduct; isatin; Lewis base; allylic alkylation; annulation
资金
- NSFC [21572135, 21931006]
- Fundamental Research Funds for the Central Universities
- Sichuan Science and Technology Program [19YYJC2413]
The development of synthetic protocols to access architectures with broad structural and functional diversity from readily available starting materials is very attractive in both organic and medicinal chemistry fields. Toward this objective, the multifunctional isatin-derived Morita-Baylis-Hillman (MBH) adducts provide opportunities to construct a variety of complex scaffolds containing a privileged oxindole motif through several catalytic pathways. By forming the ammonium or phosphonium salts with Lewis bases, isatin-derived MBH adducts can undergo allylic substitutions with a range of nucleophiles, usually in a S(N)2 '-S(N)2 ' pattern. Besides, assisted by Bronsted bases, the corresponding onium salts can be converted into the allylic ylide intermediates, which can undergo various annulation reactions or even 1,3-difunctionalizations. Moreover, recent cooperative catalysis of Lewis bases and transition metal complexes further puts forward the application of isatin-derived MBH adducts. This tutorial review covers the significant transformations of isatin-derived MBH adducts, mostly in an asymmetric version, catalyzed by various Lewis bases over the past decade.
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