期刊
CHEMICAL ENGINEERING JOURNAL
卷 375, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.121999
关键词
Electroactivity; Polyurethane-urea elastomer dressing; Shape memory; Wound healing; Aniline trimer
资金
- National Natural Science Foundation of China [51673155]
- State Key Laboratory for Mechanical Behavior of Materials
- Fundamental Research Funds for the Central Universities
- World-Class Universities (Disciplines)
- Characteristic Development Guidance Funds for the Central Universities
Development of wound dressings that not only have multiple advantages including good barrier properties, elasticity and shape memory properties, but also show anti-infection, anti-oxidative and promote cell adhesion, proliferation to enhance wound healing process, remains an ongoing challenge in the skin tissue engineering. Herein, we designed and synthesized a series of electroactive shape memory polyurethane-urea elastomers by combining the mechanical properties of polycaprolactone (PCL) segments, wettability of polyethylene glycol (PEG) segments and electroactivity of aniline trimer (AT) segments, as antibacterial, anti-oxidant and electroactive film dressing for cutaneous wound healing. The films displayed suitable hydrophilicity and swelling ratio, excellent mechanical and shape memory properties, electroactivity, free radical scavenging capacity, non-adherent property and biocompatibility. Excitingly, the electroactive film with an optimal concentration of 12 wt% AT promoted mouse fibroblasts (L929) adhesion and proliferation, and it also significantly accelerated in vivo wound healing process than no-electroactive film and commercial dressing (Tegaderm (TM) film) through promoting granulation tissue thickness and collagen deposition in a full-thickness skin defect model. Moreover, after loading with vancomycin as antibacterial agents, the rate of wound healing is further enhanced. In summary, the electroactive shape memory polyurethane-urea films significantly promoted in vivo wound healing process attributed to its multifunctional properties indicated that they are excellent candidates as film wound dressing.
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