期刊
CEREBRAL CORTEX
卷 30, 期 3, 页码 1752-1767出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhz200
关键词
cortical plate; fetus; in vivo MRI; subplate; transient fetal compartments
资金
- Ralph Schlaeger Foundation in Neuroradiology
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [K23NS101120]
- American Academy of Neurology Clinical Research Training Fellowship
- NARSAD Young Investigator Award from the Brain and Behavior Foundation
- National Institutes of Health [R01EB018988, R01NS106030, R01EB013248]
- Technological Innovations in Neuroscience Award from the McKnight Foundation
Structural asymmetries and sexual dimorphism of the human cerebral cortex have been identified in newborns, infants, children, adolescents, and adults. Some of these findings were linked with cognitive and neuropsychiatric disorders, which have roots in altered prenatal brain development. However, little is known about structural asymmetries or sexual dimorphism of transient fetal compartments that arise in utero. Thus, we aimed to identify structural asymmetries and sexual dimorphism in the volume of transient fetal compartments (cortical plate [CP] and subplate [SP]) across 22 regions. For this purpose, we used in vivo structural T2-weighted MRIs of 42 healthy fetuses (16.43-36.86 gestational weeks old, 15 females). We found significant leftward asymmetry in the volume of the CP and SP in the inferior frontal gyrus. The orbitofrontal cortex showed significant rightward asymmetry in the volume of CP merged with SP. Males had significantly larger volumes in regions belonging to limbic, occipital, and frontal lobes, which were driven by a significantly larger SP. Lastly, we did not observe sexual dimorphism in the growth trajectories of the CP or SP. In conclusion, these results support the hypothesis that structural asymmetries and sexual dimorphism in relative volumes of cortical regions are present during prenatal brain development.
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