期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 77, 期 1, 页码 35-59出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03368-y
关键词
DNA polymerase; Replication; DNA repair; Structural biology; DNA synthesis
资金
- National Institutes of Environmental Health Sciences of the National Institutes of Health [R35GM128562]
DNA polymerases are vital for the synthesis of new DNA strands. Since the discovery of DNA polymerase I in Escherichia coli, a diverse library of mammalian DNA polymerases involved in DNA replication, DNA repair, antibody generation, and cell checkpoint signaling has emerged. While the unique functions of these DNA polymerases are differentiated by their association with accessory factors and/or the presence of distinctive catalytic domains, atomic resolution structures of DNA polymerases in complex with their DNA substrates have revealed mechanistic subtleties that contribute to their specialization. In this review, the structure and function of all 15 mammalian DNA polymerases from families B, Y, X, and A will be reviewed and discussed with special emphasis on the insights gleaned from recently published atomic resolution structures.
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