期刊
CELL STRESS & CHAPERONES
卷 24, 期 6, 页码 1013-1026出版社
SPRINGER
DOI: 10.1007/s12192-019-01040-9
关键词
Protein quality control; Protein homeostasis; Chaperones; Protein folding disease
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB1036]
- European Union's Joint Program on Neurodegenerative Diseases (JPND Project Protest, Netherlands, Netherlands Organization for Scientific Research (ZonMw))
The cellular protein quality control machinery with its central constituents of chaperones and proteases is vital to maintain protein homeostasis under physiological conditions and to protect against acute stress conditions. Imbalances in protein homeostasis also are keys to a plethora of genetic and acquired, often age-related, diseases as well as aging in general. At the EMBO Workshop, speakers covered all major aspects of cellular protein quality control, from basic mechanisms at the molecular, cellular, and organismal level to medical translation. In this report, the highlights of the meeting will be summarized.
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