期刊
CELL METABOLISM
卷 30, 期 4, 页码 630-655出版社
CELL PRESS
DOI: 10.1016/j.cmet.2019.09.001
关键词
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资金
- Research Council of Norway [262175, 277813]
- NSFC [81971327]
- Akershus University Hospital Strategic grant [269901]
- Glenn Foundation for Medical Research
- NIH [R37 AG028730, R01 AG019719, R01 DK100263]
- HELSE SoR-OST [2017056]
- Rosa Sloyfe Award project [207819]
NAD(+) is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD(+)-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD(+) and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD(+)-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.
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