期刊
CELL
卷 179, 期 4, 页码 813-827出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.10.005
关键词
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资金
- Dutch Cancer Foundation, Netherlands [10989]
- European Union [722729]
- Welfare Foundation for Social & Cultural Sciences (KIKPE), Greece
- KIKPE Foundation, Athens, Greece
- Pentagon Biotechnology, UK
- DeepMed IO, UK from the Hellenic Foundation for Research and Innovation (HFRI) [775]
- NKUA-SARG [70/3/9816, 70/3/12128, 70/3/15603]
- IRB
- Spanish Ministry of Economy
- European Regional Development Fund (ERDF) [SAF2013-48256-R]
- European Research Council [ERC-2014-AdG/669622]
- laCaixa'' Foundation
- BBSRC [BB/K017314/1, BB/S006710/1, BB/S013466/1, BB/H022384/1, BB/I020748/1] Funding Source: UKRI
- MRC [MR/P020941/1, MC_U120085810, G0601333, MR/R010013/1] Funding Source: UKRI
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
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