期刊
CELL
卷 179, 期 5, 页码 1129-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.10.031
关键词
-
资金
- Jane Coffin Childs Memorial Fund
- New York Stem Cell Foundation
- American Diabetes Association
- Rita Allen Foundation
- McKnight Foundation
- Alfred P. Sloan Foundation
- Brain and Behavior Research Foundation
- Esther A. and Joseph Klingenstein Foundation
- UCSF Program for Breakthrough Biomedical Research
- UCSF Diabetes Center
- UCSF Nutrition Obesity Research Center
- NIH New Innovator Award [DP2-DK109533]
- [R01-DK106399]
- [R01-NS094781]
Energy homeostasis requires precise measurement of the quantity and quality of ingested food. The vagus nerve innervates the gut and can detect diverse interoceptive cues, but the identity of the key sensory neurons and corresponding signals that regulate food intake remains unknown. Here, we use an approach for target-specific, single-cell RNA sequencing to generate a map of the vagal cell types that innervate the gastrointestinal tract. We show that unique molecular markers identify vagal neurons with distinct innervation patterns, sensory endings, and function. Surprisingly, we find that food intake is most sensitive to stimulation of mechanoreceptors in the intestine, whereas nutrient-activated mucosal afferents have no effect. Peripheral manipulations combined with central recordings reveal that intestinal mechanoreceptors, but not other cell types, potently and durably inhibit hunger-promoting AgRP neurons in the hypothalamus. These findings identify role for intestinal mech-anoreceptors in the regulation of feeding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据