期刊
CARBOHYDRATE POLYMERS
卷 224, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115158
关键词
Chitosan-lactose derivatives; Maillard reaction; Antioxidant activity; Cytotoxicity
资金
- Universidad Nacional de Villa Maria of Argentina
- Universidad Nacional de Rio Cuarto of Argentina [PPI-UNRC 2016-2018]
- Consejo Nacional de Investigacion Cientifica y Tecnologica of Argentina [CONICET PIO 20320150100052CO, PIP CONICET 112-2015-0100283]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCYT) of Argentina [PICTE 20140284, PICT 2015-0585]
- Ministerio de Ciencia y Tecnologia de la provincia de Cordoba (PIODO) of Argentina [0058/18]
- CONICET
In this study, water-soluble chitosan (Ch) derivatives were synthesized by the Maillard reaction between Ch and lactose. The Ch derivatives were characterized by FT-IR, H-1-NMR and SLS to determine their structure, degree of deacetylation (DD), and molecular weight (Mw). The solubility at physiological pH, the in vitro antioxidant activity against hydroxyl radical, anion superoxide radical and ABTS cation radical, and the cytotoxicity against epithelial cells of the rat ileum (IEC-18) were also evaluated. The Maillard reaction, derivatives with lower Mw and DD and greater solubility than Ch were obtained. The biological properties of the derivatives were dependent on the concentration, Mw and DD, with antioxidant activity greater than or equal to that of Ch and non-cytotoxic in a wide range of concentrations. The results indicate that Ch derivatization with lactose produces new water-soluble polysaccharides, with antioxidant activity and non-cytotoxic, which can be used as biomaterials for food and pharmaceutical applications.
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