期刊
CARBOHYDRATE POLYMERS
卷 230, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115641
关键词
N-isopropyl modified chitosan; pH-stimulus; Thermal stimulus; Hydrogel formation; Rheology
资金
- INTERREG V-A ItaliaSlovenia 2014-2020 BANDO 1/2016 ASSE 1 [BioApp 1472551605]
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good bio-compatibility as determined through preliminary viability and cell growth experiments.
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