期刊
CARBOHYDRATE POLYMERS
卷 223, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115084
关键词
Cellulose nanocrystals (CNCs); Graft; Nanocomposite hydrogel; Reversible covalent bond; Self-healing
资金
- National Natural Science Foundation of China [21574112]
- Research Institute for Forestry New Technology, Chinese Academy of Forestry [CAFINT2014K03]
- National Nonprofit Institute Research Grant of CAFINT
In this work, a novel strategy for the construction of injectable self-healing nanocomposite (NC) hydrogels dominated by reversible boronic ester bonds was demonstrated. Specifically, NC hydrogels were constructed by the solution-mixing of N, N-dimethylacrylamide-stat-3-acrylamidophenylboronicacid statistical copolymers (PDMA-stat-PAPBA) and poly(glycerolmonomethacrylate) (PGMA) chains grafted cellulose nanocrystals (CNC-g-PGMA). Rheology analysis indicated the as-constructed NC hydrogel displayed about 7-fold increase in the storage modulus with a low CNCs loading level of 1.43 wt% in comparison with PGMA/PDMA-stat-PAPBA hydrogel without CNCs. Furthermore, the mechanical strength of the CNC-g-PGMA/PDMA-stat-PAPBA hydrogel was far superior to that of its PGMA/PDMA-stat-PAPBA/CNCs hydrogel counterpart, in which PGMA chains were not covalently grafted on the surfaces of CNCs. Due to reversible boronic ester bonds cross-linking networks, CNC-g-PGMA/PDMA-stat-PAPBA NC hydrogel exhibited excellent self-healing and injectable properties as well as pH/glucose responsive sol-gel transitions. Good biocompatibility was also demonstrated through in vitro cytotoxicity tests.
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