Facile preparation of luminescent cellulose nanocrystals with aggregation-induced emission feature through Ce(IV) redox polymerization

Cellulose nanocrystals (CNCs) are a novel type of natural nanomaterials that have attracted tremendous research interest for various applications especially in the biomedical fields owing to their natural origin, biodegradable potential, remarkable biocompatibility and massive reactive hydroxyl groups. In this work, a novel strategy has been developed for fabrication of luminescent CNCs with aggregation-induced emission (AIE) feature for the first time through a facile one-step Ce(IV) redox polymerization for direct surface grafting of AIE dye (PhE) and hydrophilic monomer Poly(ethylene glycol) monomethyl ether acrylate (PEGMA) on CNCs. Various characterization techniques would demonstrate the successful preparation of resultant CNC-PhE-PEGMA with uniform nanoscale size, remarkable fluorescent properties and extremely low cytotoxicity. Furthermore, compared with conventional modification strategy of CNCs, Ce(IV) redox polymerization only need moderate temperature and can operate in aqueous solution utilizing surface hydroxyl groups of CNCs as polymerization activity sites. More importantly, CNC-PhE-PEGMA show desirable fluorescent properties and can be used for cell dyeing, indicating their potential for biomedical applications.