期刊
CARBOHYDRATE POLYMERS
卷 223, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115034
关键词
Angiogenesis; Fucoidan; Tumor; Anticancer
资金
- Northern Portugal Regional Operational Programme (NORTE 2020) [NORTE-01-0145-FEDER-000013, NORTE-01-0145-FEDER-000021, NORTE-01-0145-FEDER-000023]
- European Regional Development Fund (FEDER)
- Competitiveness Factors Operational Programme (COMPETE)
- National funds, through the Portuguese Foundation for Science and Technology (FCT) [POCI-01-0145-FEDER-007038]
- NORTE 2020 [Norte-08-5369-000037]
- FCT [SFRH/BPD/117858/2016]
- [IF/00376/2014]
Fucoidan is a marine-origin sulfated polysaccharide that can show anticancer activity, to which both pro-and anti-angiogenic responses have been reported. Due to this unpredictability, the angiogenic potential of an effective anticancer crude fucoidan (CF), at a concentration of 0.5 mg mL(-1), was evaluated. Tube formation assays demonstrated that CF, either administered while endothelial cells seeding or after their adhesion, migration and organization, inhibited or disrupted the formation of tubular-like structures, respectively. Although CF did not significantly reduced vascular endothelial growth factor (VEGF) secretion, it significantly reduced the expression of platelet-derived growth factor (PDGF), compromising the blood vessels maturation. Two chicken embryo chorioallantoic membrane (CAM) assays were performed: one without tumor (CAM I) and the other with an onplanted tumor mass (CAM II); the CF injection reduced the number of blood of vessels and significantly decreased the tumor size, respectively. In vitro and in vivo results support the effectiveness of fucoidan as a natural antitumor therapeutic agent.
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