期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 188, 期 5, 页码 736-739出版社
WILEY
DOI: 10.1111/bjh.16229
关键词
acute myeloid leukaemia; TP53; RRM2B
类别
Limited data are available on the incidence and impact of TP53 alterations and TP53 pathway deregulation in paediatric acute myeloid leukaemia (AML). We analysed TP53 alterations in bone marrow samples of 229 patients with de novo paediatric AML, and detected heterozygous missense exon mutations in two patients (1%) and 17p deletions of the TP53 gene in four patients (2%). These patients more frequently had complex karyotype (50% vs. 4%, P = 0 center dot 002) or adverse cytogenetic abnormalities, including complex karyotype (67% vs. 17%, P = 0 center dot 013), compared to TP53 wild-type. Differential expression of TP53 pathway genes was associated with poor survival, indicating a role for TP53 regulators and effector genes.
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