相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
Maria C. Donaldson-Collier et al.
NATURE GENETICS (2019)
RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2
Qi Zhang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail
Tyler M. Weaver et al.
SCIENTIFIC REPORTS (2019)
Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
Krupa S. Jani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Polycomb complexes in normal and malignant hematopoiesis
Valerio Di Carlo et al.
JOURNAL OF CELL BIOLOGY (2019)
COSMIC: the Catalogue Of Somatic Mutations In Cancer
John G. Tate et al.
NUCLEIC ACIDS RESEARCH (2019)
Ezh2 Mutations Found in the Weaver Overgrowth Syndrome Cause a Partial Loss of H3K27 Histone Methyltransferase Activity
Julian C. Lui et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits
Daniel T. Youmans et al.
GENES & DEVELOPMENT (2018)
The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells
Gundula Streubel et al.
MOLECULAR CELL (2018)
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2
Chul-Hwan Lee et al.
MOLECULAR CELL (2018)
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding
Siming Chen et al.
MOLECULAR CELL (2018)
Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
Chul-Hwan Lee et al.
MOLECULAR CELL (2018)
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
Eric Conway et al.
MOLECULAR CELL (2018)
Capturing the Onset of PRC2-Mediated Repressive Domain Formation
Ozgur Oksuz et al.
MOLECULAR CELL (2018)
MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding
Matteo Perino et al.
NATURE GENETICS (2018)
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Simon Poepsel et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Structures of human PRC2 with its cofactors AEBP2 and JARID2
Vignesh Kasinath et al.
SCIENCE (2018)
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes
Simon Poepsel et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis
Janet L. Manias Rothberg et al.
CELL DISCOVERY (2018)
Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis
F. Thol et al.
LEUKEMIA (2017)
Polycomb repressive complex 2 in an autoinhibited state
Matthew Bratkowski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/ 07 prospective clinical trial cohort
Darius Juskevicius et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines
Xueyin Wang et al.
MOLECULAR CELL (2017)
Polycomb-like proteins link the PRC2 complex to CpG islands
Haojie Li et al.
NATURE (2017)
An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED
Wei Qi et al.
NATURE CHEMICAL BIOLOGY (2017)
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex
Yupeng He et al.
NATURE CHEMICAL BIOLOGY (2017)
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Yu Liu et al.
NATURE GENETICS (2017)
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Ahmet Zehir et al.
NATURE MEDICINE (2017)
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
Xueyin Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation
Jeongyoon Choi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity
Daniel Holoch et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2
Kimberly D. Barnash et al.
ACS COMBINATORIAL SCIENCE (2017)
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
Xueyin Wang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation
Jeongyoon Choi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
Ling Li et al.
PLOS ONE (2017)
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting
Bernd Schuettengruber et al.
CELL (2017)
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding
Michael L. Curtin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
The quest for mammalian Polycomb response elements: are we there yet?
Moritz Bauer et al.
CHROMOSOMA (2016)
Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas
Ryan D. Morin et al.
CLINICAL CANCER RESEARCH (2016)
Age-related mutations and chronic myelomonocytic leukemia
C. C. Mason et al.
LEUKEMIA (2016)
EZH2 in normal hematopoiesis and hematological malignancies
Laurie Herviou et al.
ONCOTARGET (2016)
Pervasive lncRNA binding by epigenetic modifying complexes - The challenges ahead
Juan G. Betancur
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)
Comprehensive mutational profiling of core binding factor acute myeloid leukemia
Nicolas Duployez et al.
BLOOD (2016)
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia
Klaus H. Metzeler et al.
BLOOD (2016)
Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia
Cristina Lopez et al.
BRITISH JOURNAL OF HAEMATOLOGY (2016)
Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs
Anne Grijzenhout et al.
DEVELOPMENT (2016)
The interaction of PRC2 with RNA or chromatin is mutually antagonistic
Manuel Beltran et al.
GENOME RESEARCH (2016)
EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape
Robert Liefke et al.
MOLECULAR CELL (2016)
EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
Malte Beringer et al.
MOLECULAR CELL (2016)
Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma
Jia-Jie Hao et al.
NATURE GENETICS (2016)
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation
George P. Souroullas et al.
NATURE MEDICINE (2016)
The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation
Susan L. Kloet et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Genomic Classification and Prognosis in Acute Myeloid Leukemia
Elli Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
Sarah Cooper et al.
NATURE COMMUNICATIONS (2016)
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
Neil Justin et al.
NATURE COMMUNICATIONS (2016)
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Alexei Brooun et al.
NATURE COMMUNICATIONS (2016)
Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
Pierre Hirsch et al.
NATURE COMMUNICATIONS (2016)
The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation
Susan L. Kloet et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
Targeted deep sequencing improves outcome stratification in chronic myelomonocytic leukemia with low risk cytogenetic features
Laura Palomo et al.
ONCOTARGET (2016)
Routine clinical mutation profiling using next generation sequencing and a customized gene panel improves diagnostic precision in myeloid neoplasms
Stephan Bartels et al.
ONCOTARGET (2016)
Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer
Anne Laugesen et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Itys Comet et al.
NATURE REVIEWS CANCER (2016)
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
Keyur P. Patel et al.
BLOOD (2015)
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse
Manoj Garg et al.
BLOOD (2015)
Targeting EZH2 and PRC2 dependence as novel anticancer therapy
Bowen Xu et al.
EXPERIMENTAL HEMATOLOGY (2015)
JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression
Chang-Liang Su et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2015)
Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA
Chen Davidovich et al.
MOLECULAR CELL (2015)
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation
Serena Sanulli et al.
MOLECULAR CELL (2015)
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
Lianying Jiao et al.
SCIENCE (2015)
Recurrent ETNK1 mutations in atypical chronic myeloid leukemia
Carlo B. Gambacorti-Passerini et al.
BLOOD (2015)
Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2
Brooke M. Swalm et al.
ACS CHEMICAL BIOLOGY (2014)
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
Pontus Lundberg et al.
BLOOD (2014)
Nascent RNA interaction keeps PRC2 activity poised and in check
Syuzo Kaneko et al.
GENES & DEVELOPMENT (2014)
Targetable Activating Mutations are Very Frequent in GCB and ABC Diffuse Large B-Cell Lymphoma
Elodie Bohers et al.
GENES CHROMOSOMES & CANCER (2014)
The Tudor Domain of the PHD Finger Protein 1 Is a Dual Reader of Lysine Trimethylation at Lysine 36 of Histone H3 and Lysine 27 of Histone Variant H3t
Ina Kycia et al.
JOURNAL OF MOLECULAR BIOLOGY (2014)
A687V EZH2 Is a Driver of Histone H3 Lysine 27 ( H3K27) Hypertrimethylation
Heidi M. Ott et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Regulatory Interactions between RNA and Polycomb Repressive Complex 2
Catherine Cifuentes-Rojas et al.
MOLECULAR CELL (2014)
Polycomb-Dependent H3K27me1 and H3K27me2 Regulate Active Transcription and Enhancer Fidelity
Karin J. Ferrari et al.
MOLECULAR CELL (2014)
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Jessica Okosun et al.
NATURE GENETICS (2014)
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
Marco Gerlinger et al.
NATURE GENETICS (2014)
Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression
Reinhard Kalb et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification
Artyom A. Alekseyenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms
Raajit Rampal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
Jennifer A. Perry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations
Sergey I. Nikolaev et al.
NATURE COMMUNICATIONS (2014)
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Lynnette Fernandez-Cuesta et al.
NATURE COMMUNICATIONS (2014)
The Genomic Landscape of Pediatric Ewing Sarcoma
Brian D. Crompton et al.
CANCER DISCOVERY (2014)
Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations
Franck Tirode et al.
CANCER DISCOVERY (2014)
Genetics of Follicular Lymphoma Transformation
Laura Pasqualucci et al.
CELL REPORTS (2014)
EZH2 mutations are frequent and represent an early event in follicular lymphoma
Csaba Boedoer et al.
BLOOD (2013)
Clinical and biological implications of driver mutations in myelodysplastic syndromes
Elli Papaemmanuil et al.
BLOOD (2013)
EZH2 and CD79B Mutational Status Over Time in B-Cell Non-Hodgkin Lymphomas Detected by High-Throughput Sequencing Using Minimal Samples
Mauro Ajaj Saieg et al.
CANCER CYTOPATHOLOGY (2013)
Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin
Jinsook Son et al.
GENES & DEVELOPMENT (2013)
Elements of the Polycomb Repressor SU(Z) 12 Needed for Histone H3-K27 Methylation, the Interface with E(Z), and In Vivo Function
Aswathy N. Rai et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting
Ling Cai et al.
MOLECULAR CELL (2013)
The landscape of somatic mutations in Down syndrome-related myeloid disorders
Kenichi Yoshida et al.
NATURE GENETICS (2013)
Promiscuous RNA binding by Polycomb repressive complex 2
Chen Davidovich et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells
Syuzo Kaneko et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
J. Nangalia et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics
Arne H. Smits et al.
NUCLEIC ACIDS RESEARCH (2013)
Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations
Hong Wu et al.
PLOS ONE (2013)
Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain
Stephen Antonysamy et al.
PLOS ONE (2013)
Genetic heterogeneity of diffuse large B-cell lymphoma
Jenny Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
Ana Puda et al.
AMERICAN JOURNAL OF HEMATOLOGY (2012)
Mutations in EZH2 Cause Weaver Syndrome
William T. Gibson et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Activating CBL mutations are associated with a distinct MDS/MPN phenotype
Juliana Schwaab et al.
ANNALS OF HEMATOLOGY (2012)
Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
Joannah Score et al.
BLOOD (2012)
A Landscape of Driver Mutations in Melanoma
Eran Hodis et al.
CELL (2012)
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Christina R. Majer et al.
FEBS LETTERS (2012)
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Jinghui Zhang et al.
NATURE (2012)
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Michael Krauthammer et al.
NATURE GENETICS (2012)
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Panagiotis Ntziachristos et al.
NATURE MEDICINE (2012)
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
Cecilia Ballare et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
Gerard L. Brien et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
Catherine A. Musselman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
Michael T. McCabe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
Jens G. Lohr et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Molecular architecture of human polycomb repressive complex 2
Claudio Ciferri et al.
ELIFE (2012)
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
Damian B. Yap et al.
BLOOD (2011)
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
Anna M. Jankowska et al.
BLOOD (2011)
EZH2 mutational status predicts poor survival in myelofibrosis
Paola Guglielmelli et al.
BLOOD (2011)
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
Tim J. Wigle et al.
FEBS LETTERS (2011)
Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z) 12 through Partially Overlapping Binding Sites
Agnieszka J. Nowak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation
Wen Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks
Frank W. Schmitges et al.
MOLECULAR CELL (2011)
Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
V. Grossmann et al.
LEUKEMIA (2011)
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Ryan D. Morin et al.
NATURE (2011)
Frequent pathway mutations of splicing machinery in myelodysplasia
Kenichi Yoshida et al.
NATURE (2011)
EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas
Russell J. H. Ryan et al.
PLOS ONE (2011)
Temporal Dissection of Tumorigenesis in Primary Cancers
Steffen Durinck et al.
CANCER DISCOVERY (2011)
Jarid2 and PRC2, partners in regulating gene expression
Gang Li et al.
GENES & DEVELOPMENT (2010)
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
H. Makishima et al.
LEUKEMIA (2010)
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Diego Pasini et al.
NATURE (2010)
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
Gorica Nikoloski et al.
NATURE GENETICS (2010)
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Thomas Ernst et al.
NATURE GENETICS (2010)
Structural Biology of Human H3K9 Methyltransferases
Hong Wu et al.
PLOS ONE (2010)
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
Chao Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
Christopher J. Sneeringer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
Jamy C. Peng et al.
CELL (2009)
Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells
Xiaohua Shen et al.
CELL (2009)
Role of the polycomb protein EED in the propagation of repressive histone marks
Raphael Margueron et al.
NATURE (2009)
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2
Hana Kim et al.
NUCLEIC ACIDS RESEARCH (2009)
Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46
Natalia V. Murzina et al.
STRUCTURE (2008)
Structural basis of EZH2 recognition by EED
Zhifu Han et al.
STRUCTURE (2007)
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
Diego Pasini et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Hyperconserved CpG domains underlie Polycomb-binding sites
Amos Tanay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Polycomblike-2-deficient mice exhibit normal left-right asymmetry
Shusheng Wang et al.
DEVELOPMENTAL DYNAMICS (2007)
Polycomb complexes repress developmental regulators in murine embryonic stem cells
LA Boyer et al.
NATURE (2006)
Control of developmental regulator's by polycomb in human embryonic stem cells
TI Lee et al.
CELL (2006)
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
E Bernstein et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing
R Cao et al.
MOLECULAR CELL (2005)
Subunit contributions to histone methyltransferase, activities of fly and worm Polycomb group complexes
CS Ketel et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
DNA-binding properties of ARID family proteins
A Patsialou et al.
NUCLEIC ACIDS RESEARCH (2005)
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
R Cao et al.
MOLECULAR CELL (2004)
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
A Kirmizis et al.
GENES & DEVELOPMENT (2004)
Role of histone H2A ubiquitination in polycomb silencing
HB Wang et al.
NATURE (2004)
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
D Pasini et al.
EMBO JOURNAL (2004)
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
A Kuzmichev et al.
GENES & DEVELOPMENT (2002)
Role of histone H3 lysine 27 methylation in polycomb-group silencing
R Cao et al.
SCIENCE (2002)
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites
B Czermin et al.
CELL (2002)
The polycomb group protein EZH2 is involved in progression of prostate cancer
S Varambally et al.
NATURE (2002)
A Drosophila Polycomb group complex includes Zeste and dTAFII proteins
AJ Saurin et al.
NATURE (2001)
The Polycomb-group gene Ezh2 is required for early mouse development
D O'Carroll et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Site-specific recognition of a 70-base-pair element containing d(GA)n repeats mediates bithoraxoid polycomb group response element-dependent silencing
JW Hodgson et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Structure of a Polycomb response element and in vitro binding of Polycomb group complexes containing GAGA factor
B Horard et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)