期刊
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12906-019-2715-1
关键词
Benign breast disease; Berberis vulgaris; Insulin-like growth factor; PPAR; VEGF; HIF
资金
- Tabriz University of Medical Sciences, Tabriz, Iran [5-97-1295]
- Nutrition Research Center [5-71-291]
Background The present study was designed to investigate the effects of Berberis vulgaris (BV) juice consumption on plasma levels of insulin-like growth factor (IGF-1), IGF-binding proteins (IGFBPs), and the expression of PPAR-gamma, VEGF and HIF in women with benign breast disease. Methods This parallel design randomized, double-blind controlled clinical trial was conducted on 85 eligible patients diagnosed with benign breast disease. They were assigned randomly into either BV juice group (n = 44, BV juice: 480 ml/day) or placebo group (n = 41, BV placebo juice: 480 ml/day) for 8 weeks intervention. Participants, caregivers and those who assessed laboratory analyses were blinded to the assignments. Plasma levels of biomarkers were measured at baseline and after 8 weeks by ELISA. Quantitative real-time PCR was used to measure the fold change in the expression of each interested gene. Results The compliance of participants was 95.2% and 40 available subjects analyzed in each group at last. Relative treatment (RT) effects for BV juice caused 16% fall in IGF-1 concentration and 37% reduction in the ratio of IGF-1/1GFBP1. Absolute treatment effect expressed 111 ng/ml increased mean differences of IGFBP-3 between BV group and placebo. Plasma level of PPAR-gamma increased in both groups but it was not significant. Fold changes in the expressions of PPAR-gamma, VEGF and HIF showed down-regulation in the intervention group compared to placebos (P < 0.05). Conclusions The BV juice intervention over 8 weeks was accompanied by acceptable efficacy and decreased plasma IGF-1, and IGF-1/IGFBP-1 ratio partly could be assigned to enhanced IGFBP-1 level in women with BBD. The intervention caused reductions in the expression levels of PPAR, VEGF, and HIF which are remarkable genomic changes to potentially prevent breast tumorigenesis.
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